Premium
Radical‐Induced, Palladium‐Catalyzed C–H Activation: An Approach to Functionalize 4 H ‐Benzo[ d ][1,3]oxazin‐4‐one Derivatives by Using Toluenes, Aldehydes, and Benzyl Alcohols
Author(s) -
Kumar Prashant,
Gupta Mohit,
Bahadur Vijay,
Parmar Virinder S.,
Singh Brajendra K.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800263
Subject(s) - chemistry , catalysis , palladium , surface modification , benzyl alcohol , medicinal chemistry , combinatorial chemistry , organic chemistry
Toluenes, aldehydes, and benzyl alcohols have been utilized in the radical‐induced direct functionalization of 4 H ‐benzo[ d ][1,3]oxazin‐4‐one derivatives by using a palladium‐catalyzed C–H activation strategy. The stability, low toxicity, and ease of access to toluenes, aldehydes, and benzyl alcohols have made them suitable candidates for this transformation. The reaction proceeded smoothly with high functional group compatibility and afforded the desired products in moderate to good yields. Mechanistic investigations illustrate the radical pathway and highlight the importance of both catalyst and oxidant.