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Cobalt(II)‐Catalyzed N ‐Acylation of Amines through a Transamidation Reaction
Author(s) -
Ma Juan,
Zhang Feng,
Zhang Jingyu,
Gong Hang
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800253
Subject(s) - chemistry , catalysis , acylation , cobalt , primary (astronomy) , dimethylformamide , organic chemistry , combinatorial chemistry , reaction conditions , medicinal chemistry , solvent , physics , astronomy
A practical protocol has been developed for a Co(OAc) 2 · 4H 2 O‐catalyzed transamidation reaction. The reaction gives high yields and uses N , N ‐dimethylformamide and other amides as carbonyl sources. The protocol is rapid and simple, and it does not require any acids, bases, ligands, or other additives. It works well for a wide range of primary, secondary, and heterocyclic amines.