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Organocatalytic Enantioselective Synthesis of Tetrahydropyridines
Author(s) -
Dudog Yohan,
Rodriguez Jean,
Constantieux Thierry,
Bugaut Xavier
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800236
Subject(s) - enantioselective synthesis , stereocenter , organocatalysis , reflection (computer programming) , combinatorial chemistry , computer science , biochemical engineering , chemistry , catalysis , organic chemistry , engineering , programming language
Tetrahydropyridines are important heterocycles present in many molecules of natural and non‐natural origins that exhibit a wide array of biological activities. With several sp 3 ‐hybridized carbon atoms in their structure, they often include one or several stereogenic centers, whose control represents a great synthetic challenge. For the past two decades, enantioselective organocatalysis has developed as a very powerful strategy to perform the synthesis of enantioenriched compounds, including heterocycles. In this Microreview, we wish to provide the readers with a general overview about the organocatalytic strategies that have been used to achieve the preparation of diversified families of tetrahydropyridines, thereby providing elements of reflection for further developments.