Highly Efficient Synthesis and Structure–Activity Relationships of a Small Library of Substituted 1,4‐Naphthoquinones | Zendy

Bao Na | Zendy; Ou Jinfeng | Zendy; Shi Wei | Zendy; Li Na | Zendy; Chen Li | Zendy; Sun Jianbo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Highly Efficient Synthesis and Structure–Activity Relationships of a Small Library of Substituted 1,4‐Naphthoquinones

Author(s) -

Bao Na,

Ou Jinfeng,

Shi Wei,

Li Na,

Chen Li,

Sun Jianbo

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201800207

Subject(s) - plumbagin , chemistry , combinatorial chemistry , naphthoquinone , stereochemistry , structure–activity relationship , organic chemistry , biochemistry , in vitro , genetics , biology

A platform of highly efficient synthetic methodologies has been established to access a focused library of substituted 1,4‐naphthoquinones derivatives functionalized with a diversity of amino/hydroxy/alkyl groups. Furthermore, the structure–activity relationship deduced from antiproliferative activities and toxicities of this 1,4‐naphthoquinone library and intracellular reactive oxygen species (ROS) level detections might warrant future potential of plumbagin ( 2 ) and compound 13 as promising basic structures to develop novel anti‐cancer agents.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research