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Transition Metal‐Free sp 3 C–H Functionalization of Arylacetic Acids for the Synthesis of 1,3,5‐Triazines
Author(s) -
Pardeshi Sachin D.,
Sathe Pratima A.,
Pawar Balu V.,
Vadagaonkar Kamlesh S.,
Chaskar Atul C.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800178
Subject(s) - chemistry , benzamidine , benzaldehyde , surface modification , hydrochloride , condensation , transition metal , organic chemistry , combinatorial chemistry , guanidine , catalysis , physics , thermodynamics , enzyme
A one‐pot simple, efficient and practically viable protocol for the synthesis of substituted 1,3,5‐triazines has been reported from arylacetic acids and benzamidine hydrochloride. In addition, we demonstrated first transition metal‐free conversion of phenylacetic acid to benzaldehyde which on condensation with two equivalents of benzamidine hydrochloride offered 2,4,6‐trisubstituted 1,3,5‐triazines. This protocol is environmentally benign and economically viable which makes it feasible for gram scale synthesis.