Premium
Forging Amides Through Metal‐Catalyzed C–C Coupling with Isocyanates
Author(s) -
Serrano Eloisa,
Martin Ruben
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800175
Subject(s) - chemistry , synthon , amide , catalysis , combinatorial chemistry , coupling reaction , organic chemistry , organic synthesis , peptide bond , carbon fibers , materials science , composite number , composite material , enzyme
The natural occurrence of amides and their unique roles in synthetic materials and biologically active compounds make amide synthesis one of the most routinely performed reactions in organic chemistry. Despite the advances achieved, there is a growing need for the design of new catalytic technologies to complement existing amide bond‐forming reactions, which are often based on the formation of carbon–nitrogen bonds. Recent years have witnessed the development of a new disconnection approach to forging amides by means of metal‐catalyzed carbon–carbon bond‐forming reactions. This microreview highlights the most recent developments in the use of isocyanates in metal‐catalyzed amidations that take place according to this design principle. With the aim of illustrating the prospective impact of the use of isocyanates as amide synthons, this review highlights the advantages and drawbacks of the existing methods and describes the mechanistic implications when appropriate.