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Asymmetric Organocatalysis and Photoredox Catalysis for the α‐Functionalization of Tetrahydroisoquinolines
Author(s) -
Hou Hong,
Zhu Shaoqun,
Atodiresei Iuliana,
Rueping Magnus
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800117
Subject(s) - chemistry , photoredox catalysis , organocatalysis , enamine , catalysis , alkylation , catalytic cycle , enantioselective synthesis , amine gas treating , surface modification , synergistic catalysis , organic chemistry , combinatorial chemistry , photocatalysis
The asymmetric α‐alkylation of tetrahydroisoquinolines with cyclic ketones has been accomplished in the presence of a combined catalytic system consisting of a visible‐light photoredox catalyst and a chiral primary amine organocatalyst. The desired products were obtained in good yields, high enantioselectivity, and good to excellent diastereoselectivity. (PC: photoredox cycle, EN: enamine cycle).