Asymmetric Organocatalysis and Photoredox Catalysis for the α‐Functionalization of Tetrahydroisoquinolines | Zendy

Hou Hong | Zendy; Zhu Shaoqun | Zendy; Atodiresei Iuliana | Zendy; Rueping Magnus | Zendy

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Asymmetric Organocatalysis and Photoredox Catalysis for the α‐Functionalization of Tetrahydroisoquinolines

Author(s) -

Hou Hong,

Zhu Shaoqun,

Atodiresei Iuliana,

Rueping Magnus

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201800117

Subject(s) - chemistry , photoredox catalysis , organocatalysis , enamine , catalysis , alkylation , catalytic cycle , enantioselective synthesis , amine gas treating , surface modification , synergistic catalysis , organic chemistry , combinatorial chemistry , photocatalysis

The asymmetric α‐alkylation of tetrahydroisoquinolines with cyclic ketones has been accomplished in the presence of a combined catalytic system consisting of a visible‐light photoredox catalyst and a chiral primary amine organocatalyst. The desired products were obtained in good yields, high enantioselectivity, and good to excellent diastereoselectivity. (PC: photoredox cycle, EN: enamine cycle).

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