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Copper(II) Catalyzed C–H Alkoxylation of 2‐Phenyl Pyridines with Aliphatic Diols
Author(s) -
Xiao Yan,
Li Juan,
Liu Yajun,
Wang Shuo,
Zhang Hui,
Ding Huaiwei
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800104
Subject(s) - chemistry , catalysis , regioselectivity , copper , diol , surface modification , organic chemistry , reaction conditions , coupling reaction , combinatorial chemistry , medicinal chemistry
A very simple copper(II) catalyzed C–O coupling reaction of 2‐phenylpyridines and aliphatic diols was achieved by using a strategy of C–H functionalization. A series of aroxyl ethanols are easily obtained with the yields of 30–67 %. Various functional groups, as well as different length of aliphatic diols are well tolerated in the developed catalytic system. This new protocol featurs a simple reaction system, economical catalyst and good regioselectivity. In addition, a “one‐pot” synthesis of 2‐phenyl pyridines was developed.