Premium
Copper(II) Catalyzed C–H Alkoxylation of 2‐Phenyl Pyridines with Aliphatic Diols
Author(s) -
Xiao Yan,
Li Juan,
Liu Yajun,
Wang Shuo,
Zhang Hui,
Ding Huaiwei
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800104
Subject(s) - chemistry , catalysis , regioselectivity , copper , diol , surface modification , organic chemistry , reaction conditions , coupling reaction , combinatorial chemistry , medicinal chemistry
A very simple copper(II) catalyzed C–O coupling reaction of 2‐phenylpyridines and aliphatic diols was achieved by using a strategy of C–H functionalization. A series of aroxyl ethanols are easily obtained with the yields of 30–67 %. Various functional groups, as well as different length of aliphatic diols are well tolerated in the developed catalytic system. This new protocol featurs a simple reaction system, economical catalyst and good regioselectivity. In addition, a “one‐pot” synthesis of 2‐phenyl pyridines was developed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom