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Front Cover: Structural and Computational Investigation of Intramolecular N···H Interactions in α‐ and β‐Fluorinated 7‐Azaindoline Amides (Eur. J. Org. Chem. 6/2018)
Author(s) -
Brewitz Lennart,
Noda Hidetoshi,
Kumagai Naoya,
Shibasaki Masakatsu
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800098
Subject(s) - chemistry , intramolecular force , nitrogen atom , amide , substituent , front cover , hydrogen bond , hydrogen atom , nitrogen , crystallography , atom (system on chip) , computational chemistry , stereochemistry , cover (algebra) , molecule , ring (chemistry) , organic chemistry , group (periodic table) , mechanical engineering , computer science , engineering , embedded system
The Front Cover shows an intramolecular hydrogen‐bonding interaction between the pyridyl nitrogen atom and a proton at the α‐position of the carbonyl carbon atom of a fluorinated 7‐azaindoline amide. The strength of the interaction can be tuned as a function of the electronic nature of the pyridyl nitrogen atom and the α‐substituent, which was confirmed by X‐ray crystallographic analysis, NMR analysis, and DFT calculations. More information can be found in the Full Paper by N. Kumagai, M. Shibasaki et al.