Premium
Front Cover: Synthesis and Applicability of Base‐Discriminating DNA‐Triplex‐Forming 19 F NMR Probes (Eur. J. Org. Chem. 5/2018)
Author(s) -
Bhuma Naresh,
Tähtinen Ville,
Virta Pasi
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800052
Subject(s) - nucleobase , chemistry , front cover , fluorine 19 nmr , dna , base pair , pyrimidine , proton nmr , two dimensional nuclear magnetic resonance spectroscopy , stereochemistry , nuclear magnetic resonance spectroscopy , cover (algebra) , crystallography , biochemistry , mechanical engineering , engineering
The Front Cover shows triplex‐forming 19 F NMR probes that recognize nucleobase content in the pyrimidine‐rich strand of double‐helical DNA targets. The obtained 19 F NMR resonances are sensitive to the base content, and unique 19 F NMR‐spectral fingerprints could be obtained. The idea of the probes may find application in studies in which the goal is to simultaneously detect changes of local environments (e.g., upon binding of nucleobase‐specific ligands) in structurally resembling double‐helical stretches. More information can be found in the Full Paper by N. Bhuma, V. Tähtinen, and P. Virta .