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Metal‐Free Iodine‐Mediated Deoxygenation of Alcohols in the Position α to Electron‐Withdrawing Groups
Author(s) -
Pichon Maëva M.,
Stauffert Fabien,
AddanteMoya Luis G.,
Bodlenner Anne,
Compain Philippe
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800051
Subject(s) - deoxygenation , nitrile , iodine , chemistry , pyridine , primary (astronomy) , metal , organic chemistry , medicinal chemistry , polymer chemistry , catalysis , physics , astronomy
The use of a substoichiometric amount of molecular iodine in the presence of PPh 3 and pyridine effects a direct deoxygenation of primary and secondary alcohols in positions α to a variety of activating electron‐withdrawing groups, including ketones, esters, amides, imides and nitrile groups.