An Efficient Synthesis of  N , N , N ‐Substituted 1,4,7‐Triazacyclononane | Zendy

Huang Yong | Zendy; Liu Yajing | Zendy; Liu Song | Zendy; Wu Renbo | Zendy; Wu Zehui | Zendy

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An Efficient Synthesis of N , N , N ‐Substituted 1,4,7‐Triazacyclononane

Author(s) -

Huang Yong,

Liu Yajing,

Liu Song,

Wu Renbo,

Wu Zehui

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201800048

Subject(s) - chemistry , alkylation , medicinal chemistry , reaction conditions , combinatorial chemistry , reduction (mathematics) , stereochemistry , organic chemistry , catalysis , geometry , mathematics

A new and efficient synthetic approach is reported for various N , N , N ‐substituted 1,4,7‐triazacyclononanes (TACN) in moderate to excellent yields, with optimization of the reaction sequences and conditions of the intermediate 1,4,7‐tribenzyl‐1,4,7‐triazonane‐2,6‐dione reduction with LiAlH 4 , removal of benzyl with Pd/C, and alkylation reactions. This reaction scheme provides a convenient and flexible method to prepare various N , N , N ‐substituted TACN derivatives.

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