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An Efficient Synthesis of N , N , N ‐Substituted 1,4,7‐Triazacyclononane
Author(s) -
Huang Yong,
Liu Yajing,
Liu Song,
Wu Renbo,
Wu Zehui
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800048
Subject(s) - chemistry , alkylation , medicinal chemistry , reaction conditions , combinatorial chemistry , reduction (mathematics) , stereochemistry , organic chemistry , catalysis , geometry , mathematics
A new and efficient synthetic approach is reported for various N , N , N ‐substituted 1,4,7‐triazacyclononanes (TACN) in moderate to excellent yields, with optimization of the reaction sequences and conditions of the intermediate 1,4,7‐tribenzyl‐1,4,7‐triazonane‐2,6‐dione reduction with LiAlH 4 , removal of benzyl with Pd/C, and alkylation reactions. This reaction scheme provides a convenient and flexible method to prepare various N , N , N ‐substituted TACN derivatives.