Premium
Synthesis of 3‐Iodobenzofurans by Electrophilic Cyclization under Solventless Conditions in a Ball Mill
Author(s) -
Mantovani Anderson C.,
Hernández José G.,
Bolm Carsten
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800027
Subject(s) - electrophile , chemistry , ball mill , iodine , environmentally friendly , organic chemistry , solvent , combinatorial chemistry , catalysis , chemical engineering , ecology , engineering , biology
Under mechanochemical conditions, electrophilic cyclizations of 2‐alkynylanisoles provide 3‐iodobenzofurans in the absence of a solvent. Equimolar amounts of iodine are sufficient for achieving good yields. The eco‐friendly reaction conditions are mild, and various functional groups are tolerated.