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Front Cover: Directed ortho ‐Metalation of O ‐Aryl N , N ‐Dialkylcarbamates: Methodology, Anionic ortho ‐Fries Rearrangement, and Lateral Metalation (Eur. J. Org. Chem. 4/2018)
Author(s) -
Miah M. A. Jalil,
Sibi Mukund P.,
Chattopadhyay S.,
Familoni Oluwole B.,
Snieckus Victor
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201800016
Subject(s) - fries rearrangement , metalation , chemistry , aryl , ring (chemistry) , medicinal chemistry , front cover , carbamate , pericyclic reaction , benzene , stereochemistry , organic chemistry , cover (algebra) , catalysis , mechanical engineering , alkyl , engineering
The Front Cover shows a wheel centered on the aryl ortho ‐lithiated O‐carbamate represented by the maple leaf (imagine a benzene ring) and by two ethyl hockey‐stick groups (both symbolic to Canada), the carbamate's partial history, its anionic equivalency to the venerable Fries rearrangement, and its rich chemistry. Follow the wheel from 12 o'clock in an R configuration passing through a carbamate used for treatment of a neuromuscular disease, through Karl Fries, and ending in directed ortho ‐metalation (D o M), anionic ortho‐Fries rearrangement (A o F), and walking‐around‐the‐ring DoM – all very useful reactions for synthetic aromatic chemistry. More information can be found in the Full Papers ( ejoc.201701142 and ejoc.201701143 ) by M. A. J. Miah, V. Snieckus et al.