Acid‐Promoted Cascade Reaction of  N ‐(4‐Chloroquinolin‐3‐yl)carbamates with Amines: One‐Pot Assembly of Imidazo[4,5‐ c ]quinolin‐2‐ones | Zendy

Lu Xiao | Zendy; Kim Myunghoon | Zendy; Orr Meghan J. | Zendy; Li Hao | Zendy; Huang Wenwei | Zendy

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Acid‐Promoted Cascade Reaction of N ‐(4‐Chloroquinolin‐3‐yl)carbamates with Amines: One‐Pot Assembly of Imidazo[4,5‐ c ]quinolin‐2‐ones

Author(s) -

Lu Xiao,

Kim Myunghoon,

Orr Meghan J.,

Li Hao,

Huang Wenwei

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201701772

Subject(s) - chemistry , intramolecular force , amination , intermolecular force , cascade reaction , coupling reaction , combinatorial chemistry , cascade , sequence (biology) , reaction conditions , reductive amination , medicinal chemistry , stereochemistry , organic chemistry , molecule , catalysis , biochemistry , chromatography

An acid‐promoted cascade reaction of N ‐(4‐chloroquinolin‐3‐yl)carbamates with amines is described. This method achieves the formation of two new C–N bonds through an intermolecular amination/intramolecular cyclization reaction sequence. In combination with a subsequent Suzuki coupling reaction, this three‐component telescopic procedure provides rapid access to various bioactive imidazo[4,5‐ c ]quinolin‐2‐one derivatives.

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