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Copper‐Catalyzed S ‐Arylation Starting from Arylboronic Acids and Tetraalkylthiuram Disulfide
Author(s) -
Xu Wan,
Gao Fan,
Dong ZhiBing
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701757
Subject(s) - chemistry , aryl , catalysis , combinatorial chemistry , disulfide bond , substrate (aquarium) , copper , coupling reaction , organic chemistry , biochemistry , oceanography , alkyl , geology
A convenient and useful protocol for the synthesis of diverse S ‐aryl dithiocarbamates was studied. Starting from arylboronic acid and tetraalkylthiuram disulfide, copper‐catalyzed C–S coupling proceeds smoothly to give the desired S ‐aryl dithiocarbamates in good to excellent yields. The broad substrate scope, short reaction time, easy performance, cheap substrates, and nice yields make this approach attractive, showing its practical synthetic value for the preparation of some biologically or pharmaceutically active compounds.