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Synthesis of α‐Fluorinated Acrylates by a Palladium‐Catalyzed Decarboxylative Olefination Reaction
Author(s) -
Bouazzaoui Ouafa,
Rousée Kevin,
Mulengi Joseph Kajima,
Pannecoucke Xavier,
Bouillon JeanPhilippe,
CouveBonnaire Samuel
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701709
Subject(s) - chemistry , decarboxylation , palladium , catalysis , organic chemistry , ligand (biochemistry) , combinatorial chemistry , biochemistry , receptor
Ligand‐free palladium‐catalyzed subsequent decarboxylation/olefination reaction between 2‐fluorinated acrylates and benzoic acids is reported. Valuable trisubstituted 2‐fluoroacrylates and 2‐trifluoromethylacrylates were produced in low to excellent yields, which constitutes a new interesting greener synthetic alternative to these fluorinated molecules.