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Synthesis of Trifluoroacetyl‐Substituted Cyclopropanes Using Onium Ylides
Author(s) -
Winter Michael,
Gaunersdorfer Christina,
Roiser Lukas,
Zielke Katharina,
Monkowius Uwe,
Waser Mario
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701699
Subject(s) - chemistry , onium , organic chemistry , ylide , combinatorial chemistry , computational chemistry , ion
The use of carbonyl‐stabilized ammonium‐ and sulfonium ylides allows for the synthesis of highly‐functionalized trifluoroacetyl‐substituted cyclopropanes. It turned out that the diastereoselectivities strongly depend on the nature of the chosen ylide and the employed base. The products could be obtained in good yields under operationally simple conditions.