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Enantioselective Direct Synthesis of syn ‐ and anti ‐α,β‐Dihydroxy γ‐Keto Esters Using a Dinuclear Zinc–AzePhenol Complex
Author(s) -
Zhang ZhaoFei,
Yang XiaoChao,
Lu HuiJie,
Wang MinCan
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701695
Subject(s) - enantioselective synthesis , chemistry , zinc , aldol reaction , yield (engineering) , stereochemistry , catalysis , organic chemistry , combinatorial chemistry , materials science , metallurgy
A one‐step enantioselective direct synthesis of both syn ‐ and anti ‐α,β‐dihydroxy γ‐keto esters using a dinuclear zinc–AzePhenol complex is presented. This asymmetric α‐hydroxyacetate aldol reaction proceeds in moderate to good yield and with excellent enantioselectivity of up to 99 % ee . The desired products could be used as versatile intermediates for several transformations.