Enantioselective Direct Synthesis of  syn ‐ and  anti ‐α,β‐Dihydroxy γ‐Keto Esters Using a Dinuclear Zinc–AzePhenol Complex | Zendy

Zhang ZhaoFei | Zendy; Yang XiaoChao | Zendy; Lu HuiJie | Zendy; Wang MinCan | Zendy

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Enantioselective Direct Synthesis of syn ‐ and anti ‐α,β‐Dihydroxy γ‐Keto Esters Using a Dinuclear Zinc–AzePhenol Complex

Author(s) -

Zhang ZhaoFei,

Yang XiaoChao,

Lu HuiJie,

Wang MinCan

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201701695

Subject(s) - enantioselective synthesis , chemistry , zinc , aldol reaction , yield (engineering) , stereochemistry , catalysis , organic chemistry , combinatorial chemistry , materials science , metallurgy

A one‐step enantioselective direct synthesis of both syn ‐ and anti ‐α,β‐dihydroxy γ‐keto esters using a dinuclear zinc–AzePhenol complex is presented. This asymmetric α‐hydroxyacetate aldol reaction proceeds in moderate to good yield and with excellent enantioselectivity of up to 99 % ee . The desired products could be used as versatile intermediates for several transformations.

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