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A TBPB‐Mediated C‐3 Cycloalkylation and Formamidation of 4‐Arylcoumarin
Author(s) -
Joychandra Singh Sarangthem,
Ahmad Mir Bilal,
Patel Bhisma K.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701677
Subject(s) - chemistry , chlorobenzene , formamide , acetic acid , scope (computer science) , organic chemistry , medicinal chemistry , catalysis , computer science , programming language
A tert ‐butyl peroxybenzoate (TBPB) mediated cycloalkylation and formamidation efficiently took place at 120 °C in chlorobenzene or the corresponding formamide, respectively. The cycloalkylation required the addition of acetic acid, whereas the formamidation proceeded in its absence. This radical‐mediated process tolerated a broad scope of substrates and provided the products in moderate to good yields.