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One‐Pot Synthesis of Highly Substituted Pyrroles by Three‐Component Reactions of Donor–Acceptor Cyclopropanes, Salicylaldehydes, and Ammonium Acetate
Author(s) -
Su Zhenjie,
Gu Wenxing,
Qian Siran,
Xue Shuwen,
Wang Cunde
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701674
Subject(s) - chemistry , annulation , aromatization , ammonium acetate , acceptor , ring (chemistry) , combinatorial chemistry , substrate (aquarium) , organic chemistry , ammonium , catalysis , physics , high performance liquid chromatography , oceanography , geology , condensed matter physics
An efficient one‐pot synthesis of highly substituted pyrroles from donor–acceptor cyclopropanes, salicylaldehydes, and ammonium acetate has been developed. This reaction involves a domino sequence involving the ring‐opening of donor–acceptor cyclopropanes, [3+2] annulation, and aromatization as the key steps. This elegant methodology readily afforded functionalized pyrroles under mild reaction conditions and with a wide substrate scope.