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A One‐Pot Cascade Reaction by Combining NH‐Sulfoximines with Thiophenols Under Mild Conditions
Author(s) -
Peng Yao,
Lin Yan,
Nie Ruifang,
Zheng Yang,
Liu Yanzhao,
Guo Li,
Wu Yong
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701643
Subject(s) - chemistry , cascade , reaction conditions , sulfur , cascade reaction , combinatorial chemistry , catalysis , protocol (science) , functional group , organic chemistry , chromatography , medicine , polymer , alternative medicine , pathology
A general protocol for the N ‐thioetherification of NH‐sulfoximines has been developed. Catalyzed by [Cu(DMAP) 4 I]I, N ‐sulfenyl sulfoximines were synthesized by a one‐pot cascade reaction with commercially available thiophenols as the sulfur source at room temperature. The protocol has mild reaction conditions, is operationally simple, and affords the corresponding products with good yields and excellent tolerance of functional groups.