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[Pd]‐Catalyzed Intermolecular Coupling and Acid Mediated Intramolecular Cyclodehydration: One‐Pot Synthesis of Indenes
Author(s) -
Niharika Pedireddi,
Satyanarayana Gedu
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701622
Subject(s) - chemistry , intramolecular force , intermolecular force , regioselectivity , heck reaction , catalysis , combinatorial chemistry , organic chemistry , palladium , molecule
An efficient one‐pot synthesis of indenes from simple starting materials is presented. This process involves a dual C–C bond formation through an intermolecular Heck coupling reaction followed by acid‐mediated intramolecular cyclodehydration. The strategy is amenable to various substituted aromatics to give indenes. In addition, the regioselective synthesis of benzyl styrenes in a single column purification technique through in‐situ reduction of Heck products (ketones) followed by acid mediated dehydration of crude reaction mixture is presented.