Premium
Radical‐Mediated Formal C(sp 2 )–H Functionalization of Aldehyde‐Derived N , N ‐Dialkylhydrazones
Author(s) -
Prieto Alexis,
Bouyssi Didier,
Monteiro Nuno
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701600
Subject(s) - chemistry , hypervalent molecule , aldehyde , surface modification , reagent , heteroatom , alkylation , stereochemistry , formal synthesis , medicinal chemistry , organic chemistry , catalysis , ring (chemistry)
Recent advances in formal C(sp 2 )–H functionalization of aldehyde‐derived N , N ‐dialkylhydrazones (substitution at the azomethine carbon atom) are highlighted, with a focus on radical‐mediated processes that open up new opportunities for C–C bond formation, such as alkylation reactions with the aid of hypervalent iodonium reagents or polyhaloalkanes, as well as for carbon–heteroatom bond formation (C–N, C–P). Cascade sequences based on these reactions, and leading to (hetero)cyclic frameworks, are also discussed.