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Visible‐Light‐Promoted Copper‐Catalyzed Regioselective Benzylation of Pyridine N ‐Oxides versus Thermal Acylation Reaction with Toluene Derivatives
Author(s) -
Kianmehr Ebrahim,
Gholamhosseyni Maral
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701586
Subject(s) - chemistry , toluene , pyridine , catalysis , regioselectivity , acylation , photochemistry , copper , dissociation (chemistry) , organic chemistry , medicinal chemistry
Copper‐catalyzed visible light mediated direct C–H bond benzylation of pyridine N ‐oxides with toluene derivatives was accomplished by recent developments in photochemical carbon–carbon bond formation through a photo‐induced bond‐dissociation strategy. This visible light driven protocol has been successfully applied to a broad scope of pyridine N ‐oxides and toluene derivatives. Furthermore, preliminary research indicates that the acylation reaction can be carried out under thermal reaction conditions. This protocol provides easy access to 2‐benzyl and 2‐acyl pyridine N ‐oxide derivatives in the presence of a copper catalyst.