Premium
Zinc(II)‐Catalyzed Synthesis of Propargylamines by Coupling Aldimines and Ketimines with Alkynes
Author(s) -
Shehzadi Syeda Aaliya,
Saeed Aamer,
Lemière Filip,
Maes Bert U. W.,
Abbaspour Tehrani Kourosch
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701567
Subject(s) - aldimine , chemistry , imine , alkyne , catalysis , reagent , lewis acids and bases , coupling reaction , organic chemistry , zinc , combinatorial chemistry , polymer chemistry
A Zn II ‐catalyzed reaction between imines, which were derived from unactivated aldehydes or ketones and primary amines or α‐amino acid esters, and terminal alkynes has led to the rapid and efficient formation of tri‐ and tetrasubstituted propargylamines (from aldimines and ketimines, respectively) in good to excellent yields. No additives or extra Lewis acid reagents were required for the imine‐alkyne coupling reaction.