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Continuous Flow Synthesis of Urea‐Containing Compound Libraries Based on the Piperidin‐4‐one Scaffold
Author(s) -
RiescoDomínguez Alejandra,
BlancoAnia Daniel,
Rutjes Floris P. J. T.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701539
Subject(s) - chemistry , flow chemistry , continuous flow , urea , scaffold , combinatorial chemistry , flow (mathematics) , nanotechnology , organic chemistry , biochemical engineering , catalysis , computer science , programming language , materials science , engineering , geometry , mathematics
The advantages of performing reactions in continuous flow vs. the classic batch processes render flow chemistry a suitable technique for library synthesis. Inspired by our recent work to create fluorine‐containing nitrogen heterocycles and by the potential of the urea group in drug design, we herewith describe the combination of both aspects in the continuous flow synthesis of two libraries of urea derivatives based on the piperidin‐4‐one scaffold.