Ruthenium‐Catalyzed Reductive Amidation without an External Hydrogen Source | Zendy

Yagafarov Niyaz Z. | Zendy; Muratov Karim M. | Zendy; Biriukov Klim | Zendy; Usanov Dmitry L. | Zendy; Chusova Olga | Zendy; Perekalin Dmitry S. | Zendy; Chusov Denis | Zendy

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Ruthenium‐Catalyzed Reductive Amidation without an External Hydrogen Source

Author(s) -

Yagafarov Niyaz Z.,

Muratov Karim M.,

Biriukov Klim,

Usanov Dmitry L.,

Chusova Olga,

Perekalin Dmitry S.,

Chusov Denis

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201701527

Subject(s) - chemistry , ruthenium , catalysis , carbon monoxide , cyclopentadienyl complex , hydrogen , alkylation , combinatorial chemistry , primary (astronomy) , organic chemistry , physics , astronomy

A catalytic reaction between aldehydes and primary amides that leads to N ‐alkylated amides was investigated. The developed protocol employs carbon monoxide as a deoxygenative agent and, therefore, avoids the use of an external hydrogen source. Cyclopentadienyl ruthenium complexes provided excellent catalytic efficiency and could be used with loadings as low as 0.5–1 mol‐%. A representative number of secondary amides were successfully prepared in yields of 70–84 %.

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