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Ruthenium‐Catalyzed Reductive Amidation without an External Hydrogen Source
Author(s) -
Yagafarov Niyaz Z.,
Muratov Karim M.,
Biriukov Klim,
Usanov Dmitry L.,
Chusova Olga,
Perekalin Dmitry S.,
Chusov Denis
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701527
Subject(s) - chemistry , ruthenium , catalysis , carbon monoxide , cyclopentadienyl complex , hydrogen , alkylation , combinatorial chemistry , primary (astronomy) , organic chemistry , physics , astronomy
A catalytic reaction between aldehydes and primary amides that leads to N ‐alkylated amides was investigated. The developed protocol employs carbon monoxide as a deoxygenative agent and, therefore, avoids the use of an external hydrogen source. Cyclopentadienyl ruthenium complexes provided excellent catalytic efficiency and could be used with loadings as low as 0.5–1 mol‐%. A representative number of secondary amides were successfully prepared in yields of 70–84 %.