Premium
Electrophilic Oxidation of Stereodefined Polysubstituted Silyl Ketone Aminals
Author(s) -
Huang Jian Qiang,
Nairoukh Zackaria,
Marek Ilan
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701516
Subject(s) - chemistry , silylation , ketone , electrophile , diol , organic chemistry , catalysis
We reported herein a practical approach to acyclic tertiary α‐hydroxy carbonyl compounds in only two chemical steps from alkynes with excellent diastereoselectivity through the oxidation of stereodefined polysubstituted silyl ketone aminals. The products could be smoothly converted to synthetically useful enantiomerically enriched 1,2‐diol derivatives.