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Recent Advances in Pd‐Catalyzed Cross‐Coupling Reaction in Ionic Liquids
Author(s) -
Li Jianxiao,
Yang Shaorong,
Wu Wanqing,
Jiang Huanfeng
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701509
Subject(s) - chemistry , sonogashira coupling , catalysis , coupling reaction , combinatorial chemistry , ionic liquid , allylic rearrangement , palladium , organic synthesis , surface modification , ionic bonding , cascade , coupling (piping) , organic chemistry , ion , mechanical engineering , engineering , chromatography
Ionic liquids (ILs) can behave as green solvents in comparison with conventional organic solvents, but more often they also act as ligands, co‐catalysts, and stabilizing agents both for metal active species and for intermediates of catalytic systems. In this review we have mainly summarized the recent achievements (2013 to the present) in Pd‐catalyzed cross‐coupling in ILs for the assembly of structurally diverse and highly functionalized organic molecules, with the focus on cascade reactions triggered by nucleopalladation, Suzuki coupling, Sonogashira coupling, allylic functionalization, and other types of coupling. The reaction conditions, regio‐ and stereoselectivities, and mechanisms are summarized in detail. We also highlight important and representative examples and synthetic applications of these coupling reactions. We hope that this review will result in further focused research to widen the comprehension and application of ILs in the future.