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Selective N ‐Monoalkylation of 6‐Aminouracils with Alcohols: An Environmentally Benign Protocol for the Synthesis of 6‐Alkylaminouracils
Author(s) -
Putra Anggi Eka,
Oe Yohei,
Ohta Tetsuo
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701445
Subject(s) - chemistry , alkylation , catalysis , yield (engineering) , combinatorial chemistry , iridium , organic chemistry , materials science , metallurgy
A highly selective N ‐alkylation of 6‐aminouracils with alcohols was achieved through the borrowing hydrogen approach using iridium catalysis. 6‐Aminouracils and alcohols reacted in the presence of [Cp*IrI 2 ] 2 to give 6‐monoalkyluracils selectively and in high yield (up to 99 %), usually in short reaction times (2 h). These results provide a new, green, and efficient protocol for the synthesis of 6‐alkylaminouracils, which are very important intermediates for the synthesis of biologically active molecules.