Premium
How to Synthesise High Purity, Crystalline d ‐Glucaric Acid Selectively
Author(s) -
Armstrong Robert D.,
Kariuki Benson M.,
Knight David W.,
Hutchings Graham J.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701343
Subject(s) - chemistry , yield (engineering) , azeotrope , molecule , organic chemistry , materials science , distillation , metallurgy
Glucaric acid has potential applications in food, pharmaceutical and polymer industries yet no methodology exists within the public domain for isolation of this key bio‐derived platform molecule as a pure, crystalline solid. Here we demonstrate the difficulties, which arise in doing so and report development of a process for derivation of free‐glucaric acid from its Ca 2+ /K + glucarate salts, which are both commercially available. Employing Amberlyst‐15 (H + ) exchange resin and azeotrope drying, powdered glucaric acid is prepared at > 99.96 % purity in 98.7 % dry yield.