How to Synthesise High Purity, Crystalline  d ‐Glucaric Acid Selectively | Zendy

Armstrong Robert D. | Zendy; Kariuki Benson M. | Zendy; Knight David W. | Zendy; Hutchings Graham J. | Zendy

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How to Synthesise High Purity, Crystalline d ‐Glucaric Acid Selectively

Author(s) -

Armstrong Robert D.,

Kariuki Benson M.,

Knight David W.,

Hutchings Graham J.

Publication year - 2017

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201701343

Subject(s) - chemistry , yield (engineering) , azeotrope , molecule , organic chemistry , materials science , distillation , metallurgy

Glucaric acid has potential applications in food, pharmaceutical and polymer industries yet no methodology exists within the public domain for isolation of this key bio‐derived platform molecule as a pure, crystalline solid. Here we demonstrate the difficulties, which arise in doing so and report development of a process for derivation of free‐glucaric acid from its Ca 2+ /K + glucarate salts, which are both commercially available. Employing Amberlyst‐15 (H + ) exchange resin and azeotrope drying, powdered glucaric acid is prepared at > 99.96 % purity in 98.7 % dry yield.

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