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Catalytic Asymmetric Reactions Involving the Seven‐Membered Cyclic Imine Moieties Present in Dibenzo[ b , f ][1,4]oxazepines
Author(s) -
De Munck Lode,
Vila Carlos,
Pedro José R.
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701279
Subject(s) - chemistry , imine , enantioselective synthesis , electrophile , catalysis , combinatorial chemistry , substrate (aquarium) , scope (computer science) , stereochemistry , organic chemistry , oceanography , computer science , programming language , geology
The dibenzo[ b , f ][1,4]oxazepine scaffold is a privileged structure in medicinal chemistry that displays a wide variety of biological and pharmacological activities. However, catalytic asymmetric methodologies for the synthesis of chiral dibenzo[ b , f ][1,4]oxazepine derivatives are scarce in the literature. This microreview presents an overview of enantioselective reactions in which these cyclic seven‐membered imines are used as electrophiles, including their substrate scope, limitations and application to the synthesis of related compounds.