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Palladium Catalyzed Direct Acylation of Iodo‐Acetanilides/Iodo‐Phenyl Acetates: Domino One‐Pot Synthesis of 2‐Quinolinones
Author(s) -
Basuli Scuhand,
Satyanarayana Gedu
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701250
Subject(s) - chemistry , acylation , acetanilide , domino , catalysis , intramolecular force , aldol condensation , palladium , aldol reaction , organic chemistry , one pot synthesis , acyl group , combinatorial chemistry , group (periodic table)
Pd‐catalyzed direct acylation reaction of iodoacetanilides/iodophenyl acetates with aldehydes is presented. Simple, bench‐top aldehydes were used as non‐toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without directing group assistance. The strategy was applied to a domino one‐pot synthesis of 2‐quinolinones through acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one‐pot synthesis of drugs and bioactive compounds.