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Silver‐Catalyzed Decarboxylative Radical Addition/Cyclization of α,α‐Difluoroarylacetic Acids with Acrylamides To Synthesize Difluorinated Oxindoles
Author(s) -
Li YinLong,
Wang JiBo,
Wang XueLin,
Cao Yang,
Deng Jun
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701248
Subject(s) - chemistry , catalysis , decarboxylation , radical cyclization , combinatorial chemistry , functional group , organic chemistry , reaction conditions , polymer
A facile silver‐catalyzed decarboxylative radical addition/cyclization reaction of α,α‐difluoroarylacetic acids and acrylamides has been disclosed. The method provides a highly attractive approach to synthesize a series of difluorinated oxindoles that contain various functional groups in moderate to good yields under mild conditions. Moreover, experimental studies reveal that the CF 2 group of the α,α‐difluoroarylacetic acids plays a vital role in the transformation.