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Ionic Liquids for Fast and Solvent‐Free Nucleophilic Trifluoromethylthiolation of Alkyl Halides and Alcohols
Author(s) -
Anselmi Elsa,
Simon Cédric,
Marrot Jérôme,
Bernardelli Patrick,
Schio Laurent,
Pégot Bruce,
Magnier Emmanuel
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701222
Subject(s) - chemistry , ionic liquid , halide , alkyl , reagent , nucleophile , organic chemistry , solvent , functional group , green chemistry , ionic bonding , combinatorial chemistry , catalysis , ion , polymer
The trifluoromethylthio group is of rising interest in medicinal, agrochemical, and materials chemistry. Although several strategies for the introduction of this functional group have been described, new synthetic methods are needed. A novel ionic liquid, 1‐ n ‐butyl‐3‐methylimidazolium trifluoromethylthiolate, has been developed and is herein reported as an efficient and recyclable in situ generated trifluoromethylthiolating reagent for alkyl halides, sulfonates, and even unactivated alcohols under solvent‐free conditions.