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Palladium‐Catalyzed Base‐Promoted Arylation of Unactivated C(sp 3 )–H Bonds by Aryl Iodides: A Practical Approach To Synthesize β‐Aryl Carboxylic Acid Derivatives
Author(s) -
Gou Quan,
Liu Gang,
Zhou Lanxiu,
Chen Suiyun,
Qin Jun
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701215
Subject(s) - chemistry , aryl , palladium , catalysis , combinatorial chemistry , carboxylic acid , organic chemistry , base (topology) , mathematical analysis , alkyl , mathematics
A highly efficient protocol for the β‐arylation of carboxylic amides by aryl iodides under PdCl 2 (CH 3 CN) 2 /CsOAc catalysis was developed. This method was found to tolerate a broad scope of substrates and was successfully employed in the preparation of a variety of β‐aryl α‐amino and γ‐amino acid derivatives. The utility of this method was further illustrated in the synthesis of the psychotropic drug (±)‐phenibut and β‐aryl bile acid analogues.