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Front Cover: Hydroiodination‐Triggered Cascade Reaction with I 2 /PPh 3 /H 2 O: Metal‐Free Access to 3‐Substituted Phthalides from 2‐Alkynylbenzoates (Eur. J. Org. Chem. 36/2017)
Author(s) -
Kawaguchi Shinichi,
Nakamura Kentaro,
Yamaguchi Kotaro,
Sato Yuki,
Gonda Yuhei,
Nishioka Masaaki,
Sonoda Motohiro,
Nomoto Akihiro,
Ogawa Akiya
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701210
Subject(s) - cascade , chemistry , cascade reaction , front cover , triphenylphosphine , cover (algebra) , reagent , metal , medicinal chemistry , organic chemistry , catalysis , mechanical engineering , chromatography , engineering
The Front Cover shows a cascade reaction under metal‐free conditions. The reaction depicts a waterfall (cascade) and a place that is not usually associated with a metal (forest). Easily available reagents, i.e., triphenylphosphine, iodine, and water, trigger the cascade reaction, which includes desilylation, hydroiodination, cyclization, and reduction to give phthalides from 2‐(trimethylsilylalkynyl)benzoates. We acknowledge Tamami Yamaguchi for taking the picture of a waterfall at Plitvice Lakes National Park. More information can be found in the Communication by S.‐i. Kawaguchi, A. Ogawa, et al.