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Ambient‐Light‐Promoted Perfluoroalkylative Cyclization of β,γ‐Unsaturated Hydrazones: Synthesis of Perfluoroalkylated Pyrazolines
Author(s) -
Yu Jingmiao,
Cai Chun
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701201
Subject(s) - chemistry , hydrazone , radical initiator , radical cyclization , organic chemistry , combinatorial chemistry , polymerization , polymer
An ambient‐light‐promoted, metal‐free strategy for the direct perfluoroalkylative cyclization of β,γ‐unsaturated hydrazones was developed. The radical process allowed the multifunctionalization of β,γ‐unsaturated hydrazones and selectively yielded perfluoroalkylated pyrazolines in good to excellent yields. The reaction was performed in the presence of a wide range of functional groups under mild reaction conditions and was operationally simple.