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A Flexible Synthetic Approach to Phosphatidylglycerols
Author(s) -
Gag MarieClaude,
Dautrey Sébastien,
Bertrand Xavier,
Auger Michèle,
Paquin JeanFrancois
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701178
Subject(s) - glycidol , chemistry , sequence (biology) , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , biochemistry
We report a 5‐step sequence for the synthesis of phosphatidylglycerols (PG) bearing different or identical chains at positions sn ‐1 and sn ‐2 starting from phenyl dichlorophosphate and using ( S )‐glycidol as the chiral source. Overall, this new approach is more convergent that the previously reported syntheses as the PG derivatives are constructed around the phosphorus center. Hence, this method is more convenient for the incorporation of expensive or complex acyl chains at the sn ‐2 position.