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Ruthenium‐Catalyzed Difluoroalkylation of 8‐Aminoquinoline Amides at the C5‐Position
Author(s) -
Chen Changpeng,
Zeng Runsheng,
Zhang Jingyu,
Zhao Yingsheng
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701150
Subject(s) - ruthenium , chemistry , catalysis , selectivity , combinatorial chemistry , position (finance) , organic chemistry , economics , finance
A ruthenium‐catalyzed highly selective difluoromethylation of 8‐aminoquinoline amides at the C5 position has been developed. It tolerates a broad range of functional groups, providing the corresponding difluoromethylated products in moderate to good yields. Preliminary experimental results indicate that the tricoordinate ruthenium intermediate is the key factor in achieving the C5‐position selectivity.