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Front Cover: A Mild and Chemoselective Hydrosilylation of α‐Keto Amides by Using a Cs 2 CO 3 /PMHS/2‐MeTHF System (Eur. J. Org. Chem. 33/2017)
Author(s) -
Kumar Govindharaj,
Muthukumar Alagesan,
Sekar Govindasamy
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701135
Subject(s) - hydrosilylation , chemistry , amide , front cover , ketone , solvent , chemoselectivity , orange (colour) , medicinal chemistry , organic chemistry , catalysis , cover (algebra) , mechanical engineering , engineering , food science
The Front Cover shows the reduction of α‐keto amides to α‐hydroxy amides through a Cs 2 CO 3 ‐catalyzed chemoselective hydrosilylation using polymethyl hydrosiloxane (PMHS) in 2‐methyltetrahydrofuran (2‐MeTHF), demonstrated by a football game. The boy kicks the orange ball of the Cs 2 CO 3 /PMHS system from the green ground of 2‐MeTHF, a green solvent that hits the α‐keto amide to form the α‐hydroxy amide without affecting the isolated ketone, represented by the green thumbs‐up and red thumbs‐down cartoons. The glowing‐bulb cartoon on the N–H functionality denotes the role of the free N–H group that directs the chemoselective hydrosilylation through a chelation with in situ generated MeSiH 3 . More information can be found in the Full Paper by G. Sekar et al.