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3D‐Printed Polypropylene Continuous‐Flow Column Reactors: Exploration of Reactor Utility in S N Ar Reactions and the Synthesis of Bicyclic and Tetracyclic Heterocycles
Author(s) -
Rao Zenobia X.,
Patel Bhaven,
Monaco Alessandra,
Cao Zi Jing,
BarniolXicota Marta,
Pichon Enora,
Ladlow Mark,
Hilton Stephen T.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701111
Subject(s) - bicyclic molecule , chemistry , polypropylene , aniline , flow chemistry , organic chemistry , solvent , combinatorial chemistry , continuous flow , ring (chemistry) , catalysis , biochemical engineering , engineering
3D printing has the potential to transform the way in which chemical reactions are carried out due to its low‐cost, ease‐of‐use as a technology and its capacity to expedite the development of iteratively enhanced prototypes. In this present study, we developed a novel, low‐cost polypropylene (PP) column reactor that was incorporated into an existing continuous‐flow reactor for the synthesis of heterocycles. The utility and solvent resistance of the printed devices were explored in S N Ar reactions to produce substituted aniline derivatives and in the synthesis of bicyclic and tetracyclic heterocycles. Using this approach, a range of heterocyclic compounds was synthesised including the core structure of the natural product (±)‐γ‐lycorane and structurally complex compounds based on the tetracyclic core of the erythrina alkaloids.