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Palladium‐Catalyzed Direct Synthesis of Phenanthridones from Benzamides through Tandem N–H/C–H Arylation
Author(s) -
Banerji Biswadip,
Chatterjee Satadru,
Chandrasekhar K.,
Nayan Chinmay,
Killi Sunil Kumar
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701039
Subject(s) - chemistry , palladium , catalysis , tandem , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , materials science , composite material
We report a palladium‐catalyzed method for the direct synthesis of phenanthridones from benzamides in a single step. Unlike previous reports, the current protocol does not need any directing groups or any harsh conditions. This methodology has a wide functional group tolerance therefore a series of phenanthridones were synthesized with a yield up to 87 %. The efficacy of this protocol was further explored by synthesizing some important naturally occurring amaryllidaceae alkaloids in a single step with very good yields.