Palladium‐Catalyzed Direct Synthesis of Phenanthridones from Benzamides through Tandem N–H/C–H Arylation | Zendy

Banerji Biswadip | Zendy; Chatterjee Satadru | Zendy; Chandrasekhar K. | Zendy; Nayan Chinmay | Zendy; Killi Sunil Kumar | Zendy

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Palladium‐Catalyzed Direct Synthesis of Phenanthridones from Benzamides through Tandem N–H/C–H Arylation

Author(s) -

Banerji Biswadip,

Chatterjee Satadru,

Chandrasekhar K.,

Nayan Chinmay,

Killi Sunil Kumar

Publication year - 2017

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201701039

Subject(s) - chemistry , palladium , catalysis , tandem , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , materials science , composite material

We report a palladium‐catalyzed method for the direct synthesis of phenanthridones from benzamides in a single step. Unlike previous reports, the current protocol does not need any directing groups or any harsh conditions. This methodology has a wide functional group tolerance therefore a series of phenanthridones were synthesized with a yield up to 87 %. The efficacy of this protocol was further explored by synthesizing some important naturally occurring amaryllidaceae alkaloids in a single step with very good yields.

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