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Arylative Cyclization of Indole‐1‐carboxamides with 1,6‐Enynes for the Synthesis of Polycyclic Indole Scaffolds
Author(s) -
Reddy Chatrala Ravikumar,
Yarlagadda Suresh,
Sridhar Balasubramanian,
Reddy Basi V. Subba
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701029
Subject(s) - annulation , indole test , alkyne , chemistry , michael reaction , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
A new alkyne annulation strategy has been developed for the synthesis of polycyclic indole derivatives through a cascade of C–H annulation and Michael addition reactions. This is the first report on sequential alkyne annulation and aza‐Michael addition reactions of indole‐1‐carboxamides with alkyne tethered substrates.