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Efficient Synthesis of Highly Functionalized Spirocarbocyclic Oxindoles through Hauser Annulation
Author(s) -
Lokesh Kanduru,
Kesavan Venkitasamy
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201701023
Subject(s) - annulation , chemistry , indoline , combinatorial chemistry , naphthalene , organic chemistry , catalysis
The synthesis of highly functionalized spirocarbocyclic oxindoles was accomplished for the first time, using a Hauser annulation strategy. A reaction between methyleneindolinones and arylsulfonylphthalides catalyzed by cesium carbonate gave access to a new class of biologically important spiro[indoline‐3,2′‐naphthalene] derivatives in very good yields.