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Sequence‐Specific DNA Recognition with Designed Peptides
Author(s) -
Boga Sonia,
Bouzada David,
García Peña Diego,
Vázquez López Miguel,
Vázquez M. Eugenio
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700988
Subject(s) - supramolecular chemistry , dna , chemistry , computational biology , molecular recognition , peptide , dna sequencing , combinatorial chemistry , sequence (biology) , nanotechnology , biochemistry , molecule , biology , organic chemistry , materials science
Inspired by natural transcription factors (TFs), researchers have explored the potential of artificial peptides for the recognition of specific DNA sequences, developing increasingly sophisticated systems that not only display excellent DNA binding properties, but also are endowed with new properties not found in their natural counterparts. Here we review some of the developments in the field of artificial peptide‐based DNA binders, focusing on the supramolecular and molecular design aspects of such systems.