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Solvent‐Free Synthesis of Cyanoformamides from Carbamoyl Imidazoles
Author(s) -
Nugent Jeremy,
Campbell Sarah G.,
Vo Yen,
Schwartz Brett D.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700974
Subject(s) - chemistry , combinatorial chemistry , solvent , organic chemistry
A straightforward and solvent‐free synthesis of various secondary and tertiary cyanoformamides from carbamoyl imidazoles and TMSCN has been developed. Both cyclic and acyclic carbamoyl imidazoles react smoothly to form the relevant cyanoformamides in excellent yields, often within minutes.