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Synthesis of Pyrrole‐Annulated Heterocycles through Copper‐Catalyzed Site‐Selective Dehydrogenative Cross‐Coupling
Author(s) -
Tripathi Krish.,
Ray Devalina,
Singh Ravi P.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700929
Subject(s) - chemistry , pyrrole , intramolecular force , catalysis , azole , coupling (piping) , medicinal chemistry , combinatorial chemistry , stereochemistry , photochemistry , organic chemistry , antifungal , medicine , dermatology , mechanical engineering , engineering
A method for the Cu‐catalyzed, intramolecular dehydrogenative cross‐coupling of 3‐substituted and 3,4‐disubstituted pyrrole–azole systems was developed. The C–H bond in the C2 position was site‐selectively activated over the C–H bond in the C5 position of unsymmetrically substituted pyrroles, and the six‐ and seven‐membered annulated pyrrole products were directly accessed in moderate to good yields.