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General Method for the Synthesis of 1,4‐Disubstituted 5‐Halo‐1,2,3‐triazoles
Author(s) -
Gribanov Pavel S.,
Topchiy Maxim A.,
Karsakova Iuliia V.,
Chesnokov Gleb A.,
Smirnov Alexander Yu.,
Minaeva Lidiya I.,
Asachenko Andrey F.,
Nechaev Mikhail S.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700925
Subject(s) - chemistry , acetylide , halogenation , azide , halo , combinatorial chemistry , copper , n bromosuccinimide , organic chemistry , medicinal chemistry , physics , quantum mechanics , galaxy
A general method for the synthesis of 1,4‐disubstituted 5‐halo‐1,2,3‐triazoles has been developed. The one‐pot two‐step process consists of a CuAAC reaction of a copper(I) acetylide with an organic azide catalyzed by ( a NHC)CuCl, followed by halogenation with N ‐chlorosuccinimide, N ‐bromosuccinimide, or I 2 .