General Method for the Synthesis of 1,4‐Disubstituted 5‐Halo‐1,2,3‐triazoles | Zendy

Gribanov Pavel S. | Zendy; Topchiy Maxim A. | Zendy; Karsakova Iuliia V. | Zendy; Chesnokov Gleb A. | Zendy; Smirnov Alexander Yu. | Zendy; Minaeva Lidiya I. | Zendy; Asachenko Andrey F. | Zendy; Nechaev Mikhail S. | Zendy

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General Method for the Synthesis of 1,4‐Disubstituted 5‐Halo‐1,2,3‐triazoles

Author(s) -

Gribanov Pavel S.,

Topchiy Maxim A.,

Karsakova Iuliia V.,

Chesnokov Gleb A.,

Smirnov Alexander Yu.,

Minaeva Lidiya I.,

Asachenko Andrey F.,

Nechaev Mikhail S.

Publication year - 2017

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201700925

Subject(s) - chemistry , acetylide , halogenation , azide , halo , combinatorial chemistry , copper , n bromosuccinimide , organic chemistry , medicinal chemistry , physics , quantum mechanics , galaxy

A general method for the synthesis of 1,4‐disubstituted 5‐halo‐1,2,3‐triazoles has been developed. The one‐pot two‐step process consists of a CuAAC reaction of a copper(I) acetylide with an organic azide catalyzed by ( a NHC)CuCl, followed by halogenation with N ‐chlorosuccinimide, N ‐bromosuccinimide, or I 2 .

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